OVERRIDING FUS AUTOREGULATION IN MICE TRIGGERS GAIN-OF-TOXIC DYSFUNCTIONS IN RNA METABOLISM AND AUTOPHAGY-LYSOSOME AXIS

Overriding FUS autoregulation in mice triggers gain-of-toxic dysfunctions in RNA metabolism and autophagy-lysosome axis

Mutations in coding and non-coding regions of FUS cause amyotrophic lateral sclerosis (ALS).The latter mutations may exert toxicity by increasing FUS accumulation.We show here that broad expression within the nervous Originals High Rise Loose system of wild-type or either of two ALS-linked mutants of human FUS in mice produces progressive motor phe

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Living with Data: Aligning Data Studies and Data Activism Through a Focus on Everyday Experiences of Datafication

In this paper I argue that there is an urgent need for more empirical research into everyday experiences of living with datafication, something that has not been prioritised in the emerging field of data studies to date.As a result of this absence, the knowledge produced within data studies is not as aligned to the aims of data activism as it Twin

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Religious intolerance: the maximum denial of alterity

It analyses aspects of religious intolerance in Brazil, its cause-and-effect relationship with radical proselytism, negative consequences for the exercise WATER BUFFALO BUTTER UNSALTED of the right to religious freedom and other human rights, some manifestations in the Brazilian multireligious scenario, some potentially effective instruments for pr

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